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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC6A4
All Species:
24.85
Human Site:
T81
Identified Species:
49.7
UniProt:
P31645
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31645
NP_001036.1
630
70325
T81
L
H
Q
G
E
R
E
T
W
G
K
K
V
D
F
Chimpanzee
Pan troglodytes
XP_001135066
630
70262
T81
L
H
Q
G
E
R
E
T
W
G
K
K
V
D
F
Rhesus Macaque
Macaca mulatta
Q9MYX0
630
70239
T81
L
H
Q
G
E
R
E
T
W
G
K
K
V
D
F
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q60857
630
70129
T81
I
H
Q
G
E
R
E
T
W
G
K
K
M
D
F
Rat
Rattus norvegicus
P31652
630
70153
T81
I
R
Q
G
E
R
E
T
W
G
K
K
M
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508462
865
94609
I311
R
E
T
W
G
K
K
I
D
F
L
L
S
V
I
Chicken
Gallus gallus
NP_998737
670
74409
T121
M
E
L
G
D
R
E
T
W
S
K
K
I
D
F
Frog
Xenopus laevis
A7Y2W8
633
71004
L91
Q
F
A
S
Q
G
C
L
G
V
W
R
V
S
P
Zebra Danio
Brachydanio rerio
NP_001035061
646
72103
W94
L
D
P
P
R
E
T
W
S
K
K
M
D
F
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P51905
622
69307
T76
V
T
E
R
T
R
E
T
W
G
Q
K
A
E
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03614
615
69247
L79
K
N
G
G
G
V
F
L
I
P
Y
S
I
M
V
Sea Urchin
Strong. purpuratus
XP_001204030
641
70931
E90
D
I
D
G
P
T
S
E
R
A
V
W
G
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
N.A.
N.A.
92.8
91.7
N.A.
38.1
77.6
42.1
68.5
N.A.
50.4
N.A.
43.6
49.4
Protein Similarity:
100
99.5
99.5
N.A.
N.A.
95.5
94.9
N.A.
52.9
85.2
60.8
80.6
N.A.
66.9
N.A.
63.3
66.6
P-Site Identity:
100
100
100
N.A.
N.A.
86.6
80
N.A.
0
60
6.6
13.3
N.A.
46.6
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
N.A.
N.A.
100
93.3
N.A.
13.3
80
20
13.3
N.A.
73.3
N.A.
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
0
0
0
9
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% C
% Asp:
9
9
9
0
9
0
0
0
9
0
0
0
9
50
0
% D
% Glu:
0
17
9
0
42
9
59
9
0
0
0
0
0
9
0
% E
% Phe:
0
9
0
0
0
0
9
0
0
9
0
0
0
9
59
% F
% Gly:
0
0
9
67
17
9
0
0
9
50
0
0
9
0
0
% G
% His:
0
34
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
17
9
0
0
0
0
0
9
9
0
0
0
17
0
9
% I
% Lys:
9
0
0
0
0
9
9
0
0
9
59
59
0
9
9
% K
% Leu:
34
0
9
0
0
0
0
17
0
0
9
9
0
0
9
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
9
17
9
0
% M
% Asn:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
9
9
9
0
0
0
0
9
0
0
0
0
9
% P
% Gln:
9
0
42
0
9
0
0
0
0
0
9
0
0
0
0
% Q
% Arg:
9
9
0
9
9
59
0
0
9
0
0
9
0
0
0
% R
% Ser:
0
0
0
9
0
0
9
0
9
9
0
9
9
9
0
% S
% Thr:
0
9
9
0
9
9
9
59
0
0
0
0
0
0
0
% T
% Val:
9
0
0
0
0
9
0
0
0
9
9
0
34
9
9
% V
% Trp:
0
0
0
9
0
0
0
9
59
0
9
9
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _